Overview of Enzyme Kinetics Module
Features in Enzyme Kinetics Module
Curve Fitting in Enzyme Kinetics Module
Graphs in Enzyme Kinetics Module
Enzyme Kinetics Module Equations
Enzyme Kinetics Module Requirement
Product Uses
Support
Automatically fit your radioligand and dose response studies for multiple compounds with replicate data. Choose from over 10 built-in equations, create a new equation or modify and existing equation to gain insight on the number of binding sites, and their affinity and accessibility for various drugs. Automatically generate a plot of mean response versus concentration and include the best-fit lines for each compound.
The Electrophysiology Module is an add-on to SigmaPlot that allows you to directly import your acquired data into SigmaPlot without the need for an additional data acquisition program. The module saves you the time and effort of manually entering data into SigmaPlot so you can start your analysis and graphing right away. Use the easy point-and-click interface to import your data from commonly used file formats including Axon Instruments ABF files, Bruxton Corporation's Acquire format and HEKA electronik's Pulse format. The file formats appear as a convenient drop down list in SigmaPlot.
The Enzyme Kinetics Module is a SigmaPlot add-on that guides you through data entry, analysis and graphing of your enzyme kinetics data. Select the study type in the customized Data Entry Wizard, choose from 56 built-in equations, then discover the best fit to characterize the reaction mechanism. Automatically display a series of graphs to quickly determine the type of inhibition. The module continues SigmaPlot's tradition of award-winning interface, ease-of-use and intelligent wizards to guide you through your analysis.
GENERAL FEATURES of SIGMAPLOT Enzyme Kinetics MODULES

  • Data Management

    • Cut and paste data from any application or enter data manually
    • Enter units for velocity, substrate and inhibitor concentration
    • Vary substrate concentration, inhibitor concentration or both
    • Allows replicate measurements
    • Handles missing values
    • Can numerically modify velocity data
    • Formatted worksheet with column protection
    • Custom labels for graph, axis and units

  • Output/Report Generation

    • Full report generation complete with statistical analysis Goodness of fit criteria includes Akaike’s Information Criterion (AIC)
    • The Data Report includes replicate mean velocities and their standard errors, the predicted and residual values from the curve fit and an indication of data outliers
    • The Statistical Report generated for each model includes the parameter values with their standard errors and 95% confidence intervals, AICc, R2, sum of squares, standard error of the regression, and the significance level for the runs test
    • The Model Comparison Report provides a comparison of the different models

 

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